Abstract
New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.
MeSH terms
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Animals
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Calcium Signaling / drug effects
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Calcium Signaling / physiology
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Cell Proliferation / drug effects
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Cells, Cultured
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Disease Models, Animal
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Humans
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Hypersensitivity, Delayed / drug therapy
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Hypersensitivity, Delayed / metabolism
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Immunosuppressive Agents / chemical synthesis*
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Immunosuppressive Agents / classification
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Immunosuppressive Agents / pharmacology*
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Intermediate-Conductance Calcium-Activated Potassium Channels / antagonists & inhibitors*
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Intermediate-Conductance Calcium-Activated Potassium Channels / chemistry
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Intermediate-Conductance Calcium-Activated Potassium Channels / physiology
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Keratinocytes / drug effects
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Keratinocytes / physiology
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Kv1.3 Potassium Channel / antagonists & inhibitors*
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Kv1.3 Potassium Channel / chemistry
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Kv1.3 Potassium Channel / physiology
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Patch-Clamp Techniques
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Potassium Channel Blockers / chemical synthesis*
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Potassium Channel Blockers / classification
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Potassium Channel Blockers / pharmacology*
Substances
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Immunosuppressive Agents
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Intermediate-Conductance Calcium-Activated Potassium Channels
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KCNN4 protein, human
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Kv1.3 Potassium Channel
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Potassium Channel Blockers